Genomics in Heart disease
Cardiac development, pathological remodelling and function in response to stress depend on the dynamic control of tissue specific gene expression by distant acting transcriptional enhancers. Recently, super-enhancers (SEs), also known as large or stretch enhancer clusters, are emerging as sentinel regulators within the gene regulatory networks that underpin cellular functions.
- Genomic ‘dark matter’
- Cardiovascular genetic switches
- Master switches
- Cardiovascular super-enhancers
- Cardiovascular SE-associated lncRNAs