Psychiatry and Neurocardiology
Health of the Heart and Mind Are Intertwined. Depression affects the entire body, not just the brain. It has been linked to low-grade inflammation, which is involved in the clogging of arteries and the rupture of cholesterol-filled plaque. Depression also boosts the production of stress hormones, which dull the response of the heart and arteries to demands for increased blood flow. It activates blood cell fragments known as platelets, making them more likely to clump and form clots in the bloodstream.